Deferiprone targets aconitase: Implication for Friedreich's ataxia treatment
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منابع مشابه
Deferiprone targets aconitase: Implication for Friedreich's ataxia treatment
BACKGROUND Friedreich ataxia is a neurological disease originating from an iron-sulfur cluster enzyme deficiency due to impaired iron handling in the mitochondrion, aconitase being particularly affected. As a mean to counteract disease progression, it has been suggested to chelate free mitochondrial iron. Recent years have witnessed a renewed interest in this strategy because of availability of...
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ژورنال
عنوان ژورنال: BMC Neurology
سال: 2008
ISSN: 1471-2377
DOI: 10.1186/1471-2377-8-20